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EU Publishes ATP 18 to the CLP Regulation

The EU has issued an 18th ATP to amend Annex VI to the CLP Regulation on Classification, Labelling and Packaging of Substances and Mixtures. This amendment will apply from November 23, 2023.

On May 3 2022, the European Union (EU) issued Regulation (EU) 2022/692 to amend Regulation (EC) 1272/2008 on Classification, Labelling and Packaging of Substances and Mixtures (CLP Regulation consolidated version to March 2022).

The latest amendment is the eighteenth adaptation to technical and scientific progress (ATP 18) to the CLP Regulation and contains changes to the list of chemicals falling under Annex VI to the CLP Regulation. This revision contains important changes to Table 3 of Part 3 under Annex VI ‘List of Harmonized Classification and Labelling of Hazardous Substances.’


  • adds 39 new entries, including two dibutyltin analogues (CAS: 2781-10-4 and 1067-33-0), bisphenol S (BPS) (CAS: 80-09-1) as a reprotoxic category 1B substance, benzophenone (CAS: 119-61-9) as a carcinogenic category 1 B substance and melamine (CAS: 108-78-1) as a carcinogenic category 2 substance;

  • Replaces 17 entries, including bisphenol A (index no 604-030-00-0) with additional classification and labelling information;

  • Deletes 1,5-naphthylene diisocyanate (Index No 615-007-00-X).

The latest amendment will become effective on November 23, 2023 – substances and mixtures may be classified, labelled and packaged in accordance with this revision before this date.

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