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Published 21st Amendment to the CLP Regulation

On January 5, 2024, the 21st amendment to the Classification, Labelling, and Packaging of hazardous chemicals (CLP) Regulation was published in the Official Journal of the European Union, amending and supplementing Annex VI.

Regulation (Council Regulation) number 2024/197, or the 21st ATP (Adaptation to technical and scientific progress) to the CLP Regulation, modifies and supplements the harmonized classifications and labels of certain substances in Annex VI (Harmonized classification and labelling of certain hazardous substances). The 21st ATP introduces 28 new harmonized entries and supplements 24 existing ones.

The 21st ATP can be applied from January 25, 2024, but it becomes mandatory to use it from September 1, 2025. This means that stakeholders have 18 months to make necessary changes to the classification and labeling of their substances and mixtures.

As part of the new ATP, the following innovations were also adopted:

  • LEAD (CAS: 7439-92-1): It is divided into two separate entries - lead powder (particle diameter <1 mm) and massive lead (particle diameter ≥ 1 mm) due to data showing a lower dissolution rate for massive lead compared to lead powder. Consequently, the existing classification of lead powder as toxic to aquatic environment (H400, H410) has been changed, and a different classification for massive lead as toxic to aquatic environment (H410) has been introduced.

  • BIOCIDAL ACTIVE SUBSTANCE BIT (1,2-benzisothiazolin-3-one): BIT faces changes in the sensitization threshold. The new ATP sets the sensitisation threshold from 0.05% to 0.036%, impacting its use in various products. This change poses a significant challenge for producers of biocidal products.

  • LITHIUM COMPOUNDS: Despite years of debate, the new ATP does not yet include the classification of reproductive toxicant 1A for lithium carbonate, lithium chloride, or lithium hydroxide (lithium compounds).

If you need assistance in keeping up with rapidly changing legislation, our team of chemical consultants is here to help. Explore our expertise and attractive offers by contacting us at

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